This is a simple script to send an email via MS’s O365 Service:
#!/usr/bin/env python3
import ssl
import smtplib
from smtplib import SMTP
from getpass import getpass
email = '''From: example-service@example.org <example-service@example.org>
To: Jay Tuckey <jay.tuckey@example.org>
Subject: Test email
Hi there, testing testing
'''
with SMTP("smtp.office365.com", port=587) as s:
sslcontext = ssl.create_default_context()
s.starttls(context=sslcontext)
p = getpass('Password for example-service@example.org: ')
s.login('example-service@example.org', p)
s.sendmail('example-service@example.org', ["jay.tuckey@example.org"], email)
Note how you need to set up an SSL context and perform .starttls() to properly create a secure connection.